The Story of Oral Chelation Therapy

The Story of Oral Chelation Therapy

Chelation therapy has been used to treat heavy metal poisoning since World War II. The term ‘chelate’ was coined by the analytical chemist, G.T. Morgan in 1920. ‘Chelate’ is the Greek word for ‘claw’. Alfred Werner, the son of a factory foreman and the ‘Father of Coordination Chemistry’, was awarded the 1913 Nobel Prize for developing this concept of chelation therapy. In chelation therapy, the ring within the molecule of the chelator captures and firmly binds the metallic ions. Thus chelation therapy treats heavy metal poisoning by forming complexes with the molecules of the heavy metal, which are then excreted in urine. Up to a certain stage, the subsequent fall in the metal stores Memphis condo rentals can help reverse the toxicity.

‘Dimercaprol’, more commonly known as BAL was the first agent used in chelating therapy. During the II World War, biochemists at Oxford State Bank of Pakistan University developed BAL as an antidote for the war gas Lewisite. Exposure to Lewisite causes acute arsenical blisters and systemic arsenic poisoning. That is how the first chelating agent, Dimercaprol, came to be known as British Anti-Lewisite (BAL). Soon the effectiveness of Dimercaprol in the chelation therapy of heavy metal poisoning became evident. Peters noted that BAL ointment had proved very successful in cases of industrial
arsenical accidents. Injectable forms of BAL were also found to be effective in chelation therapy. By 1947, 32 articles were published or in press on the therapeutic value of BAL. BAL online rate hotels became the chelation therapy of choice in arsenic, antimony, gold, and mercury poisoning.

A study conducted by Denny-Brown and Porter in 1951 found other uses mesothelioma lawyer montana of american muscle car for sell secondhand BAL as a chelating agent. BAL was noted to be an effective in chelation therapy of Wilson’s disease wherein excessive amount of Copper accumulates in the body. BAL chelates copper and removes it from body by excretion. At this time a need for better chelators was felt. BAL was found to be associated with various toxic effects and moreover, chelation therapy with BAL became ineffective in most patients after some time.

In 1956, Walsh first advocated use of Penicillamine, another chelating agent in treatment of Wilson’s disease. muscle car junk body for sale in north carolina Penicillamine was found to be more effective and less toxic. It is now commonly used in treatment of Wilson’s disease.

In the 1950s and home moms Internet Marketing 1960s, there was an explosion of publications on the effects of various chelating agents in animals and human beings. Ferdinand Munz had discovered EDTA (ethylenediamine tetraacetic acid), a synthetic amino acid with chelating properties way back in 1938. By 1951, EDTA was widely used in treatment of inorganic lead poisoning and is approved by FDA for the same.

The numerous adverse effects of BAL, and the need to give it intravenously, stimulated further research in this field. It was on the whole found to be inefficient in the mesothelioma lawyer missouri chelation therapy of chronic mercury poisoning. Water soluble derivatives of BAL, like Meso-2, 3-dimercaptosuccinic acid (DMSA) and 2, 3-dimercaptopropane-1-sulfonic acid (DMPS) were developed. They were found to be highly effective in treatment of mercury and lead poisoning.

DMSA and DMPS exhibit very low toxicity and are valuable oral chelating agents. In 1999, Baun opined that, unlike BAL, DMSA can be used in treatment of organic mercury poisoning. Patients with chronic mercury poisoning can now receive oral chelation therapy with DMSA, eliminating the need for a hospital admission. In 2003, Bose-OReilily and other found that oral DMSA was highly effective in treating chronic mercury toxicity among the inhabitants of gold-mining area in Philippines. DMSA was licensed by FDA for treatment of lead poisoning in 1991. Given their proven advantages over BAL, DMSA and DMPS have gained increased acceptance classic or muscle car dealers seattle taa wa among clinicians. They have improved the management of heavy metal poisoning.

BAL derivatives are not effective in chelating iron. Previously, deferoxamine was the only iron-chelator available which needed to be given as long intravenous infusions. Recently, deferasirox, an oral iron-chelator was developed. Deferasirox California online real estate courses is approved for oral chelation therapy for disorders like sickle cell anemia, which are characterized by excess accumulation of iron in body.

You could look up Oral Chelation therapy at Awake Nutrition (http://www.awakennutrition.com) and find further information on Oral Chelation Agents like PCA-rx (available at Oral Chelation Therapy http://www.awakennutrition.com/about.html).

Glycemic Index: Should GI Guide Your Food Choices?

Many popular diet books recommend avoiding foods with a high Glycemic Index. When you eat a food, your blood sugar level rises. The food that raises blood sugar the highest is pure table sugar. The Glycemic Index (GI) is a ratio of how high a food raises blood sugar in comparison Mississippi real estate listings to table sugar. Foods whose carbohydrates break down slowly release glucose into the bloodstream slowly, so blood sugar levels do not rise high and therefore these foods have Foreign Currency Exchange Trading low GI scores. Those that break down quickly cause a high rise in blood sugar and have a high GI. Most beans, whole grains and non-starchy San Francisco Rental Homes vegetables have travel to europe low GI; while sugars, refined grains, fruits and root vegetables have a high GI.

A carrot has almost the same GI as